Hamlet: The Game

Independent game producer mif2000 have produced an old school shareware point and click version of the play. A time limited version is available at this link, as well as a trailer. Author Deins Galanin has been interviewed by Joystiq:

One thing I'm proud of is the unique puzzles you won't see in any other game-they are very hard and extremely simple at the same time. However, my greatest pride is the way we managed to adapt the Hamlet story to the game's setting. At first glance, you may think that all the game and the play have in common is the title, but if you take a closer look, you'll realize that the game has all of the key events of the famous tragedy, as well as its main characters-although they're transformed nearly to absurdity.

I've not had time to play it yet, but the graphics bring to mind Ren and Stimpy and those other 90s Nickelodeon cartoons.